反応 #5532

反応方程式

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride

→

desired product

収率 99.7%

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

収率 99.7%

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄was washed with 3N-sodium hydroxide (50 ml)
2. 2
   抽出the aqueous layer was extracted with chloroform
3. 3
   乾燥was dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off

実験手順

After a suspension of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine.dihydrochloride (13.31 g, 50 mmoles) in chloroform (200 ml) was washed with 3N-sodium hydroxide (50 ml), the aqueous layer was extracted with chloroform, combined the chloroform layer was dried over anhydrous magnesium sulfate. After the solvent was distilled off to obtain 9.63 g of the desired product (99.7%, pale yellow oily product).

出典