反応 #5529

反応方程式

5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine

triethylamine

methylamine methanol

→

desired product

収率 47.1%

5-[2-(methylamino)ethylthio]imidazo[1,2-a]pyridine

収率 47.1%

溶媒

chloroform

反応条件

後処理

1. 1
   温度at reflux for 3 hours
2. 2
   洗浄The reaction solution was washed with an aqueous 3N-sodium hydroxide solution
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off
5. 5
   その他the residue was purified by column chromatography (eluent: methanol/chloroform=1:10)

実験手順

A solution of 5-[2-(methylsulfonyloxy)ethylthio]imidazo[1,2-a]pyridine (2.18 g, 8 mmoles), triethylamine (2.24 ml, 16 mmoles) and a 40% methylamine-methanol solution (20 ml) in chloroform (20 ml) was heated at reflux for 3 hours. The reaction solution was washed with an aqueous 3N-sodium hydroxide solution and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: methanol/chloroform=1:10) to obtain 781 mg of the desired product (47.1%, light brown oily product).

出典