反応 #55267

反応方程式

3(R),7-dimethyl octanoic acid ethyl ester

methanol

CHCl3

→

3(R),7-dimethyl octanoic acid

収率 60.0%

溶媒

NaOH

反応条件

後処理

1. 1
   その他Hydrolysis
2. 2
   その他to give 207 mg

実験手順

Hydrolysis: 400 mg. (2 mmol) of 3(R),7-dimethyl octanoic acid ethyl ester was refluxed in 6N NaOH (1 ml.) and methanol (4 ml.) for 2 hours. It was worked up as in Example 10 to give 207 mg. (60% yield) of 3(R),7-dimethyl octanoic acid (R-(+)-dihydrocitronellic acid), [α]D25 +6.81° (c=5.039, CHCl3).

出典