反応 #5524

反応方程式

2-amino-6-chloropyridine

ethyl bromopyruvate

→

desired product

収率 67.7%

2-ethoxycarbonyl-5-chloroimidazo[1,2-a]pyridine

収率 67.7%

溶媒

ethanol

反応条件

後処理

1. 1
   温度at reflux for 4 hours
2. 2
   その他After the solvent was removed
3. 3
   workup.ADDITIONchloroform was added to the residue, which
4. 4
   洗浄was washed in turn with saturated sodium bicarbonate and saturated saline
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   濃縮After the solvent was concentrated
7. 7
   workup.ADDITIONn-hexane was added to the mixture
8. 8
   その他Then, the crystals precipitated
9. 9
   ろ過were filtered off
10. 10
    洗浄washed with n-hexane

実験手順

A solution of 2-amino-6-chloropyridine (6.43 g, 50 mmoles) and ethyl bromopyruvate (9.75 g, 50 mmoles) in ethanol (150 ml) was heated at reflux for 4 hours. After the solvent was removed, chloroform was added to the residue, which was washed in turn with saturated sodium bicarbonate and saturated saline, and then dried over anhydrous magnesium sulfate. After the solvent was concentrated, n-hexane was added to the mixture. Then, the crystals precipitated were filtered off and washed with n-hexane to obtain 7.60 g of the desired product (67.6%, pale yellow crystals).

出典