反応 #55182

反応方程式

sodium hydroxide

3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

SnCl2.2H2O

Hydrogen sulfide

hydrochloric acid

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONThe solution is poured into a solution of 9 g
2. 2
   温度The mixture is heated
3. 3
   温度under reflux for 3 hours
4. 4
   その他precipitates
5. 5
   ろ過the mixture is filtered

実験手順

3.2 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester are dissolved in 40 ml. of acetic acid. The solution is poured into a solution of 9 g. of SnCl2.2H2O in 20 ml. of concentrated hydrochloric acid. The mixture is heated under reflux for 3 hours and adjusted to pH 2 with sodium hydroxide solution. Hydrogen sulfide is passed in until no more SnS precipitates and the mixture is filtered and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

出典