反応 #55180

反応方程式

hydriodic acid

3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid

NaHSO3

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONthe mixture is poured onto ice

実験手順

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, or the corresponding free hydroxy acid or 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, is heated with 2 ml. of 67% hydriodic acid and 4 ml. of acetic acid at 150° for 1 hour and the mixture is poured onto ice and decolorized with NaHSO3 solution. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°, is obtained.

出典