反応 #55100

反応方程式

2-mercaptoimidazole

3-aminopropanol

hydrobromic acid

→

2-(3-aminopropylmercapto)imidazole dihydrobromide

反応条件

後処理

1. 1
   温度under reflux for 25 hours
2. 2
   その他The reaction mixture was evaporated to dryness
3. 3
   その他the oily residual solid recrystallised twice from ethanol/ether

実験手順

A solution of 2-mercaptoimidazole (2 g.) and 3-aminopropanol (1.14 ml.) in hydrobromic acid (48%, 25 ml.) was heated under reflux for 25 hours. The reaction mixture was evaporated to dryness and the oily residual solid recrystallised twice from ethanol/ether to give 2-(3-aminopropylmercapto)imidazole dihydrobromide (3.55 g.) m.p. 160°-162°.

出典