反応 #5510

反応方程式

t-Butyl methyl 7-bromoheptylmalonate

Sodium iodide

→

t-butyl methyl 7-iodoheptylmalonate

溶媒

acetone

反応条件

後処理

1. 1
   温度at reflux for 2 hours
2. 2
   ろ過The reaction mixture is filtered
3. 3
   濃縮the filtrate is concentrated to dryness
4. 4
   workup.DISSOLUTIONThe residue is dissolved in methylene chloride
5. 5
   ろ過filtered again
6. 6
   濃縮The filtrate is concentrated to dryness

実験手順

t-Butyl methyl 7-bromoheptylmalonate (8.81 g, 25.1 mmol) is dissolved in acetone (50 ml). Sodium iodide (3.7 g, 25.1 mmol) is added and the mixture is stirred at reflux for 2 hours. The reaction mixture is filtered and the filtrate is concentrated to dryness. The residue is dissolved in methylene chloride and filtered again. The filtrate is concentrated to dryness to give t-butyl methyl 7-iodoheptylmalonate as an oil.

出典