反応 #55097

反応方程式

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

hydrogen bromide

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

溶媒

acetic acid

反応条件

後処理

1. 1
   温度under reflux for 7 hours
2. 2
   温度Cooling

実験手順

A mixture of 4-hydroxymethyl-5-methylimidazole hydrochloride (15.0 g.), cysteamine hydrochloride (11.5 g.) and a solution of hydrogen bromide in acetic acid (48%, 225 ml.) was heated under reflux for 7 hours. Cooling afforded 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (21.6 g.), m.p. 208°-211°.

出典