反応 #55095

反応方程式

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

収率 184.6%

溶媒

acetic acid

反応条件

後処理

1. 1
   温度under reflux for 10 hours
2. 2
   温度Following cooling to 15°-20°
3. 3
   その他the solid which crystallised
4. 4
   その他was collected
5. 5
   洗浄washed with isopropyl alcohol

実験手順

(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.

出典