反応 #55078

反応方程式

propiophenone

ammonium carbonate

potassium cyanide

ethanol

→

5-ethyl-5-phenyl-hydantoin

収率 66.0%

溶媒

water

反応条件

後処理

1. 1
   温度under reflux for 8 hours
2. 2
   温度The solution is cooled in a mixture of ice and salt
3. 3
   その他the hydantoin precipitates
4. 4
   その他The precipitate thus obtained
5. 5
   ろ過is filtered off
6. 6
   洗浄washed with water

実験手順

A solution of 26.8 g (0.2 mol) of propiophenone, 80 g (0.8 mol) of ammonium carbonate dissolved in 300 ml of water and 28 g (0.4 mol) of potassium cyanide in 300 ml of ethanol is heated under reflux for 8 hours, whilst stirring. The solution is cooled in a mixture of ice and salt; the hydantoin precipitates. The precipitate thus obtained is filtered off and washed with water. 27.1 g (yield: 66%) of 5-ethyl-5-phenyl-hydantoin, melting at 202° C., are obtained.

出典