反応 #55030

反応方程式

hydrogen

thiophene

ethanol

N-(4-piperidinyl)-2-pyrimidinamine

→

N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine

溶媒

methanol

2-propanone

反応条件

後処理

1. 1
   ろ過the catalyst is filtered off
2. 2
   その他the filtrate is evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in trichloromethane
4. 4
   洗浄The solution is washed successively with a diluted sodium hydroxide solution and with water
5. 5
   その他dried
6. 6
   ろ過filtered
7. 7
   その他evaporated

実験手順

To 0.5 parts of a solution of 2 parts of thiophene in 40 parts of ethanol, are added 4 parts of 2-propanone, 4.5 parts of N-(4-piperidinyl)-2-pyrimidinamine and 120 parts of methanol. The whole is hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is dissolved in trichloromethane. The solution is washed successively with a diluted sodium hydroxide solution and with water, dried, filtered and evaporated, yielding 3 parts of N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine as a residue.

出典