反応 #54970

反応方程式

N-hydroxy-2-methyl-2-phenyl-4-trichloromethyl-5,5-dichloro-6-oxotetrahydro-1,3-oxazine

phenylisocyanate

→

product

収率 39.0%

N-(phenylcarbamyloxy)-2-methyl-2-phenyl-4-trichloromethyl-5,5-dichloro-6-oxotetrahydro-1,3-oxazine

収率 39.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   その他the filtrate was evaporated under reduced pressure
3. 3
   その他to give a yellow oil
4. 4
   その他The oil crystallized from ethanol/hexane

実験手順

A solution of 8 g (0.02 mol) N-hydroxy-2-methyl-2-phenyl-4-trichloromethyl-5,5-dichloro-6-oxotetrahydro-1,3-oxazine, 2.4 g (0.02 mol) phenylisocyanate and several drops triethylamine in 90 ml dichloromethane was stirred at about 10° C. for about 2 days. The reaction mixture was filtered and the filtrate was evaporated under reduced pressure to give a yellow oil. The oil crystallized from ethanol/hexane to give 4 g of product, m.p. 154°-157° C. The product is tabulated in Table I as Compound No. 8.

出典