反応 #549413

反応方程式

2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole

2-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl- 5-nitroimidazole

2,2-diethoxyethylamine

dioxane

→

compound

2-[2-(2,2-diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

溶媒

water

反応条件

後処理

1. 1
   温度heated on the steam bath for 12 hours
2. 2
   workup.ADDITIONIt is then diluted with 500 ml
3. 3
   その他the precipitated yellow solid collected
4. 4
   その他dried
5. 5
   その他Recrystallization from 505 aqueous ethanol

実験手順

A mixture composed 9.8 g. of 2-(2-chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole, (Example 16), 11.0 g. of 2,2-diethoxyethylamine, and 250 ml. of dioxane is stirred and heated on the steam bath for 12 hours. It is then diluted with 500 ml. of cold water, cooled, and the precipitated yellow solid collected and dried. Recrystallization from 505 aqueous ethanol gives the pure compound melting at 154°-155° C.

出典