反応 #54889

反応方程式

diazomethane

4-(4-acetyl-8-hydroxytridecyl)benzoic acid

Acetic acid

→

methyl 4-(4-acetyl-8-hydroxytridecyl)benzoate

溶媒

ether

ether

反応条件

後処理

1. 1
   その他to destroy the excess diazomethane
2. 2
   洗浄the solution is washed with dilute sodium bicarbonate solution and water
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他Evaporation of volatile materials at reduced pressure

実験手順

A solution of diazomethane (approximately 2.5 g., 0.06 mole) in ether (100 ml.) is mixed with a solution of 4-(4-acetyl-8-hydroxytridecyl)benzoic acid (10.8 g., 0.03 mole) in ether (50 ml.). The resulting solution is allowed to stand 4 hours at room temperature. Acetic acid is then added to destroy the excess diazomethane and the solution is washed with dilute sodium bicarbonate solution and water and dried over sodium sulfate. Evaporation of volatile materials at reduced pressure yields methyl 4-(4-acetyl-8-hydroxytridecyl)benzoate, a colorless viscous oil.

出典