反応 #54886

反応方程式

4-acetoxy-5-propoxy-1-pentanol tosylate

sodium iodide

→

crude title compound

4-Acetoxy-5-propoxy-1-iodopentane

溶媒

acetone

反応条件

後処理

1. 1
   ろ過The precipitated sodium tosylate is filtered off
2. 2
   その他Most of the acetone is evaporated from the filtrate
3. 3
   workup.ADDITIONthe residue is treated with 300 ml
4. 4
   洗浄washed with dilute sodium thiosulfate solution, water, and brine
5. 5
   乾燥dried over sodium sulfate
6. 6
   workup.DISTILLATIONThe solvent is distilled in vacuo

実験手順

A solution of 4-acetoxy-5-propoxy-1-pentanol tosylate (61.5 g., 0.179 mole) and sodium iodide (79.5 g., 0.53 mole) in acetone (500 ml.) is allowed to stand at 25°-27° C. for 18 hours. The precipitated sodium tosylate is filtered off. Most of the acetone is evaporated from the filtrate and the residue is treated with 300 ml. of water. The oily product is taken up in ether, washed with dilute sodium thiosulfate solution, water, and brine, and dried over sodium sulfate. The solvent is distilled in vacuo to give a quantitative yield of the crude title compound as a yellowish oil which is used without further purification.

出典