反応 #54874

反応方程式

5-chloro-2-pentanone

1-bromopentane

magnesium

Acetic anhydride

→

title compound

1-Chloro-4-acetoxy-4-methylnonane

溶媒

Water

ether

反応条件

後処理

1. 1
   温度cooled to 15° C
2. 2
   workup.WAITto stand for 20 hours
3. 3
   その他the ether layer is separated
4. 4
   洗浄washed with brine
5. 5
   乾燥dried over sodium sulfate
6. 6
   workup.DISTILLATIONDistillation

実験手順

To the Grignard reagent prepared from 1-bromopentane (4.8 g., 0.04 mole) and magnesium (0.96 g., 0.04 mole) in ether is added 5-chloro-2-pentanone (6.0 g., 0.04 mole). The reaction mixture is stirred at 25° C. for 1 hour and then cooled to 15° C. Acetic anhydride (6 ml., excess) is added carefully and the solution is allowed to stand for 20 hours. Water is added, and the ether layer is separated, washed with brine, and dried over sodium sulfate. Distillation affords the title compound in 4.3 g. (46%) yield, b.p. 88° C. (0.1 mm.).

出典