反応 #54856

反応方程式

acetic acid

o-aminothiophenol

benzylpenicilloic acid

→

D-penicillamine

溶媒

water

反応条件

後処理

1. 1
   温度The mixture was heated
2. 2
   温度under reflux
3. 3
   workup.ADDITIONThe reaction mixture was then treated

実験手順

To a solution of 2.4 g (0.04 mole) of acetic acid in 20 ml of water, were added 1.38 g (0.011 mole) of o-aminothiophenol and 3.52 g (0.01 mole) of benzylpenicilloic acid. The mixture was heated under reflux, with stirring, for 2.5 hours in a nitrogen atmosphere. The reaction mixture was then treated as described in Example 6 to give D-penicillamine as colorless crystals: yield 1.03 g (69.1%), m.p. 202°-203° C.

出典