反応 #54836

反応方程式

hydrogen

hydrogen

ethyl 3-chloro-5-nitro-4-cyclohexylpenylglyoxylate

methanol

citric acid

→

ethyl 3-amino-5-chloro-4-cyclohexylphenylglyoxylate

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 17.6 g
2. 2
   その他are absorbed
3. 3
   ろ過The mixture is filtered
4. 4
   洗浄washed with methanol
5. 5
   濃縮the filtrate concentrated in vacuo

実験手順

A mixture of 17.6 g. (0.05 moles) of ethyl 3-chloro-5-nitro-4-cyclohexylpenylglyoxylate in 100 ml. of methanol containing 0.05 moles of citric acid and 1.5 g. of 5% palladium-on-carbon is shaken with hydrogen at 3 atm. pressure and 27° C. until 3 moles of hydrogen are absorbed. The mixture is filtered, washed with methanol and the filtrate concentrated in vacuo to obtain ethyl 3-amino-5-chloro-4-cyclohexylphenylglyoxylate isolated as the citrate salt.

出典