反応 #54835

反応方程式

trifluoromethyl iodide

ethyl 3-bromo-5-chloro-4-cyclohexylphenylglyoxylate

→

ethyl 3-chloro-5-trifluoromethyl-4-cyclohexylphenylglyoxylate

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度cooled
2. 2
   ろ過filtered
3. 3
   その他evaporated in vacuo
4. 4
   workup.ADDITIONof water is added to the residue
5. 5
   抽出extracted with ether
6. 6
   抽出The ether extract
7. 7
   その他is dried
8. 8
   その他evaporated to dryness
9. 9
   workup.DISTILLATIONdistilled

実験手順

To a solution of 0.01 moles of ethyl 3-bromo-5-chloro-4-cyclohexylphenylglyoxylate in 50 ml. of dimethylformamide is added 0.15 moles of trifluoromethyl iodide and 0.02 g. of copper powder. The reaction is shaken in a sealed tube for 5 hours at 140° C., cooled, filtered and evaporated in vacuo. 200 ml. of water is added to the residue and extracted with ether. The ether extract is dried, evaporated to dryness and distilled to obtain ethyl 3-chloro-5-trifluoromethyl-4-cyclohexylphenylglyoxylate.

出典