反応 #54826

反応方程式

hydrogen

hydrogen

ethyl 3-nitro-4-cyclohexylphenylglyoxylate

methanol

→

ethyl 3-amino-4-cyclohexylphenylglyoxylate

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 15.3 g
2. 2
   その他are absorbed
3. 3
   ろ過The mixture is filtered
4. 4
   洗浄washed with methanol
5. 5
   濃縮the filtrate concentrated in vacuo

実験手順

A mixture of 15.3 g. (0.05 moles) of ethyl 3-nitro-4-cyclohexylphenylglyoxylate in 100 ml. methanol containing 0.05 mole citric acid and 1.5 g. of 5% palladium-on-carbon is shaken with hydrogen at 3 atm. pressure and 27° C. until 3 moles of hydrogen are absorbed. The mixture is filtered, washed with methanol and the filtrate concentrated in vacuo to obtain ethyl 3-amino-4-cyclohexylphenylglyoxylate, isolated as the citrate salt.

出典