反応 #54741

反応方程式

sodium carbonate

p-isobutylphenylacetic acid

sulfuric acid

2,2,2-trifluoroethanol

→

p-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester

反応条件

後処理

1. 1
   温度was refluxed for 5 hours
2. 2
   抽出extracted with ether
3. 3
   その他The ether layer separated
4. 4
   濃縮concentrated
5. 5
   その他to leave an oily residue
6. 6
   workup.DISTILLATIONThe residue was distilled in vacuo

実験手順

A mixture of 1.9 g of p-isobutylphenylacetic acid, 10 ml of 2,2,2-trifluoroethanol and 1 ml of concentrated sulfuric acid was refluxed for 5 hours. After the reaction was complete, the mixture was poured into ice-water. The resulting mixture was neutralized with adding 5% sodium carbonate solution, and then extracted with ether. The ether layer separated was dehydrated and concentrated to leave an oily residue. The residue was distilled in vacuo to yield 2.3 g of p-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester as a colorless liquid, boiling at 78°-79° C./1 mmHg. Analysis-Calculated for C14H17F3O2 : C, 61.30; H, 6.25. Found: C, 61.01; H, 6.15. Mass spectrum: parent ion 274 m/e.

出典