反応 #54739

反応方程式

4-isobutylphenylacetonitrile

2,2,2-trifluoroethanol

sulfuric acid

→

4-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester

収率 51.1%

反応条件

後処理

1. 1
   温度were refluxed for 12 hours
2. 2
   抽出The resulting mixture was extracted with ether
3. 3
   その他The ether layer separated
4. 4
   濃縮concentrated
5. 5
   その他to leave an oily residue
6. 6
   workup.DISTILLATIONThe residue was distilled in vacuo

実験手順

A mixture of 1.73 g of 4-isobutylphenylacetonitrile and 10 g of 95% of 2,2,2-trifluoroethanol and 10 g of concentrated sulfuric acid were refluxed for 12 hours. After the reaction was complete, ice-water was added to the mixture. The resulting mixture was extracted with ether. The ether layer separated was dehydrated and concentrated to leave an oily residue. The residue was distilled in vacuo to give 1.4 g of 4-isobutylphenylacetic acid-2,2,2-trifluoroethyl ester as a pale yellow oil, boiling at 77°-79° C./1 mmHg. Analysis-Calculated for C14H17F3O2 : C, 61.30; H, 6.25. Found: C, 61.21; H, 6.23.

出典