反応 #54738

反応方程式

p-isobutylphenylacetic acid chloride

triethylamine

2-methoxyethanol

→

p-isobutylphenylacetic acid-2-methoxyethyl ester

収率 67.3%

反応条件

後処理

1. 1
   その他an inorganic substance produced
2. 2
   ろ過was filtered off
3. 3
   抽出The filtrate was extracted with ether
4. 4
   洗浄the extract was washed
5. 5
   洗浄The adsorbates was eluted with ether
6. 6
   その他to give an oily product
7. 7
   workup.DISTILLATIONDistillation of the product in vacuo

実験手順

To a solution of 3.5 g of p-isobutylphenylacetic acid chloride in 5.9 g of 2-methoxyethanol was added 1.6 g of triethylamine, and the mixture was stirred at room temperature for 4 hours. After the reaction was complete, an inorganic substance produced was filtered off. The filtrate was extracted with ether, and the extract was washed, dehydrated and applied over a column of silica gel. The adsorbates was eluted with ether, and the eluates were freed of ether to give an oily product. Distillation of the product in vacuo gave 2.8 g of p-isobutylphenylacetic acid-2-methoxyethyl ester as a colorless oil, boiling at 97°-98° C./1 mmHg. Analysis-Calculated for C15H22O3 : C, 71.97; H, 8.86. Found: C, 71.63; H, 8.90. Mass spectrum: parent ion 250 m/e.

出典