反応 #54696

反応方程式

1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline

sodium carbonate

sodium iodide

isopropylbromide

→

1,2,3,4,10,10a-Hexahydro-2-isopropyl-5-phenylbenz[g]isoquinoline

溶媒

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   その他are preheated to 50°
2. 2
   温度cooled
3. 3
   workup.ADDITIONpoured onto ice/water
4. 4
   抽出The organic substance is extracted with benzene
5. 5
   洗浄the extracts washed with water
6. 6
   乾燥dried over sodium sulphate
7. 7
   その他evaporated

実験手順

A mixture of 22.0 g of 1,2,3,4,10,10a-hexahydro-5phenylbenz[g]isoquinoline, 20.0 g of sodium carbonate and 0.2 g of sodium iodide in 180 ml of dimethylformamide are preheated to 50°. 16.5 g of isopropylbromide in 50 ml of dimethylformamide are added dropwise to the suspension over a 2 hour period, the reaction mixture further stirred for 3.5 hours at the same temperature, cooled and poured onto ice/water. The organic substance is extracted with benzene, the extracts washed with water, dried over sodium sulphate and evaporated and the title compound which remains converted to the fumarate form in isopropyl. M.P. 199°-200°.

出典