反応 #54664

反応方程式

p-menth-3-oyl chloride

ethanolamine

→

N-(2-hydroxyethyl)-p-menthane-3-carboxamide

溶媒

chloroform

chloroform

反応条件

後処理

1. 1
   温度The reaction mixture becomes warm
2. 2
   その他finally a yellow oil starts to separate out
3. 3
   workup.ADDITIONwas poured into water
4. 4
   その他The organic layer was separated
5. 5
   洗浄washed with dilute H2SO4
6. 6
   乾燥dried (MgSO4)
7. 7
   その他Removal of the solvent
8. 8
   workup.WAITleft a viscous oil (3.8 g.)
9. 9
   workup.DISTILLATIONThis was distilled under vacuum

実験手順

A solution of p-menth-3-oyl chloride prepared as in Example 1 (4.0g., 0.020 moles) in chloroform (30 ml.) was added dropwise to a stirred solution of ethanolamine (3 g., 0.043 moles) in chloroform (50 ml.). The reaction mixture becomes warm, goes cloudy and finally a yellow oil starts to separate out. After stirring for 2 hours at room temperature the mixture was poured into water. The organic layer was separated, washed with dilute H2SO4, and dried (MgSO4). Removal of the solvent left a viscous oil (3.8 g.). This was distilled under vacuum to yield N-(2-hydroxyethyl)-p-menthane-3-carboxamide as a colourless very viscous oil, b.p. 160°/01. mm.

出典