反応 #54655

反応方程式

acetic anhydride

nitric acid

urea

benzophenone

→

4-acetamido-3-nitrobenzophenone

収率 62.5%

溶媒

acetic acid

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONThe thick slurry was poured over ice
2. 2
   ろ過the insoluble product was filtered
3. 3
   その他to yield 17.7 g

実験手順

Twenty-three grams (0.1 m.) of 4-acetamidonbenzophenone, 50 ml. of acetic anhydride and 20 ml. of acetic acid were stirred together. A solution of 90 percent nitric acid (15 ml.), 10 ml. of acetic acid and 0.2 g. of urea was added dropwise to the benzophenone mixture. The reaction mixture was maintained at a temperature of about 50° C. during the nitration. The mixture was stirred at ambient temperature whereupon the mixture became very thick. The thick slurry was poured over ice and the insoluble product was filtered to yield 17.7 g. (62.5 percent yield) of 4-acetamido-3-nitrobenzophenone.

出典