反応 #54617

反応方程式

3-methyl-4-fluoronitrobenzene

tetrahydrofurfurylamine

→

2-methyl-4-nitro-N-tetrahydrofurfurylaniline

溶媒

water

反応条件

後処理

1. 1
   その他The expected product rapidly crystallises
2. 2
   ろ過after it has been filtered off
3. 3
   洗浄washed with water
4. 4
   その他recrystallised from ethanol
5. 5
   その他dried in vacuo, it melts at 60° C.

実験手順

A mixture of 0.2 mol (31.0 g) of 3-methyl-4-fluoronitrobenzene and 0.7 mol (70.7 g) of tetrahydrofurfurylamine is heated for one hour in an oil bath at 140° C. The reaction mixture is then poured into 400 g of ice-cooled water. The expected product rapidly crystallises; after it has been filtered off, washed with water, recrystallised from ethanol and dried in vacuo, it melts at 60° C.

出典