反応 #54602

反応方程式

7-amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

triethylamine

2-(1-Pyrryl)propanedioic acid, 3-ethyl ester

triethylamine

iso-butyl chloroformate

→

7-[[2-Carboethoxy-2-(1-pyrryl)acetyl]amino]-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

溶媒

THF

tetrahydrofuran

反応条件

後処理

1. 1
   温度the temperature is maintained at 0° C. for about 15 minutes
2. 2
   workup.STIRRINGwith stirring to the previous solution

実験手順

2-(1-Pyrryl)propanedioic acid, 3-ethyl ester, 1 equivalent and 1 equivalent of triethylamine is added to tetrahydrofuran (THF) which is cooled to 0° C. While stirring, iso-butyl chloroformate, 1 equivalent, is added and the temperature is maintained at 0° C. for about 15 minutes. A cold solution of 7-amino-7-methoxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 1 equivalent, and triethylamine, 1 equivalent, in 50% aqueous THF is added with stirring to the previous solution.

出典