反応 #54591
ord-238e2c7868bf4c0ab667f4ccfcc35579
反応条件
温度
60°CELSIUS
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他The phases are separated
- 2抽出the aqueous phase is extracted with chloroform
- 3抽出extracted with 0.1 N sodium hydroxide and with water
- 4乾燥After drying over sodium sulfate
- 5その他the chloroform is removed
実験手順
To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.