反応 #5454

反応方程式

compound

3-Ethoxycarbonyl-2-methylthio-4-oxo-6,7,8-trifluoro-4H-1-benzothiopyran

acetic acid

sulfuric acid

→

title compound

収率 54.0%

3-Carboxy-2-methylthio-4-oxo-6,7,8-trifluoro-4H-1-benzothiopyran

収率 54.0%

溶媒

water

反応条件

後処理

1. 1
   温度After cooling
2. 2
   ろ過the crystals deposited were collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

A mixture of 300 mg (0.897 mmol) of the compound of Example 111, 0.54 ml of acetic acid, 0.072 ml of concentrated sulfuric acid and 0.36 ml of water was stirred for 3 hours at 100° C. After cooling by allowing to stand, the crystals deposited were collected by filtration, washed with water, and dried to obtain 147 mg (0.481 mmol) of title compound (yield 54%).

出典