反応 #54507

反応方程式

ethyl 4-(2-methylphenyl)-3-oxobutanoate

sodium methoxide

1-bromododecane

potassium iodide

→

ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate

溶媒

ethanol

反応条件

後処理

1. 1
   その他The mixture was evaporated to a small volume
2. 2
   workup.ADDITIONdiluted with 100 parts water
3. 3
   抽出extracted with ether
4. 4
   抽出The ether extract
5. 5
   洗浄was washed with saturated sodium bicarbonate, saturated sodium chloride solution
6. 6
   乾燥dried over magnesium sulfate
7. 7
   その他Evaporation of the ether

実験手順

Three parts of ethyl 4-(2-methylphenyl)-3-oxobutanoate, 1 part of sodium methoxide, 4.6 parts of 1-bromododecane, 0.5 parts of potassium iodide and 50 parts of absolute ethanol were refluxed together for 4 hours and then stirred 18 hours at room temperature. The mixture was evaporated to a small volume, diluted with 100 parts water and extracted with ether. The ether extract was washed with saturated sodium bicarbonate, saturated sodium chloride solution and dried over magnesium sulfate. Evaporation of the ether gave 6 parts of crude ethyl 2-[(2-methylphenyl)acetyl]tetradecanoate as an oil which was not further purified.

出典