反応 #54505

反応方程式

sulfuric acid

2-methylphenylacetyl chloride

ethyl 3-oxobutanoate

magnesium

→

ethyl 2-acetyl-4-(2-methylphenyl)-3-oxobutanoate

溶媒

ether

carbon tetrachloride

ether

ethanol

反応条件

後処理

1. 1
   その他This material was prepared
2. 2
   workup.ADDITIONwas added
3. 3
   温度without cooling until the reaction
4. 4
   workup.DISSOLUTIONAfter the resulting precipitate dissolved
5. 5
   温度the solution was cooled in an ice-salt bath
6. 6
   その他The ether layer was separated
7. 7
   洗浄washed with water
8. 8
   乾燥dried over sodium sulfate

実験手順

This material was prepared according to the procedure of M. Viscontini and N. Merckling, Helvetica Chimica Acta, 35, 2280 (1952). To 2.65 parts of magnesium turnings was added 15 parts absolute ethanol at room temperature and 0.5 parts of carbon tetrachloride. As soon as the initial reaction subsides 100 parts of dry ether was added. The mixture was stirred without cooling until the reaction ceased, then 19.6 parts of ethyl 3-oxobutanoate in 20 parts of dry ether was added with ice cooling and good stirring. After the resulting precipitate dissolved, the solution was cooled in an ice-salt bath and 16 parts of 2-methylphenylacetyl chloride was slowly added. The mixture was allowed to stand overnight at room temperature and then combined with ice and sulfuric acid. The ether layer was separated, washed with water, dried over sodium sulfate and stripped to give ethyl 2-acetyl-4-(2-methylphenyl)-3-oxobutanoate as a crude oil.

出典