反応 #54492

ord-aec84fb4c016461bbde1960083f72835

反応方程式

CC(C)(C)NNCC(=O)c1ccc(O)c(CC#N)c1
5-[N-(t-butylamino)glycyl]-2-hydroxyphenylacetonitrile
CC(C)(C)N
t-butylamine
CC(C)(C)Nc1ccccc1
phenyl-t-butylamine
NC(N)=O
aminoketone
CC(C)(C)NCC(O)c1ccc(O)c(CC#N)c1
2-hydroxy-5-[1-hydroxy-2-(t-butylamino)ethyl]-benzeneacetonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The procedure of Example 1(c) is repeated with substitution of an equimolar amount of t-butylamine for phenyl-t-butylamine in that example. The resulting aminoketone, 5-[N-(t-butylamino)glycyl]-2-hydroxyphenylacetonitrile is reduced according to the procedure of Example 1(d) to yield 2-hydroxy-5-[1-hydroxy-2-(t-butylamino)ethyl]-benzeneacetonitrile.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04148908uspto-grants-1979_04