反応 #5448

反応方程式

product

5-Bromo-8-methoxy-1,2,3,4-tetrahydronaphthalene-1,2-dinitrile

NaOAc

→

desired product

収率 85.1%

8-methoxy-1,2,3,4-tetrahydronaphthalene-1,2-dinitrile

収率 85.1%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The reaction was filtered
2. 2
   その他evaporated
3. 3
   workup.DISSOLUTIONand the product was dissolved in ethyl acetate
4. 4
   洗浄washed with 5% NaHCO3
5. 5
   乾燥dried (MgSO4)
6. 6
   その他evaporated

実験手順

The product from Example 53 (2.90 g) was treated with 3.0 g 10% Pd/BaSO4 and 1.36 g NaOAc in 250 ml methanol and hydrogenated at 4 atm for 4 h. The reaction was filtered and evaporated; and the product was dissolved in ethyl acetate, washed with 5% NaHCO3, dried (MgSO4), and evaporated to yield 1.80 g of the desired product as a colorless oil. NMR (CDCl3) δ 2.30 (m, 2H), 2.80-3.20 (m, 3H), 3.91 (s, 3H), 4.39 (d, 1/3H), 4.46 (d, 2/3H), 6.87 (m, 2H), 7.27 (m, 1H).

出典