反応 #5443

反応方程式

product

8-Methoxy-2-propyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole hydrochloride

BBr3

→

white solid

8-Hydroxy-2-propyl-1,2,3,3a,8,8a-hexahydroindeno[1,2-c]pyrrole hydrobromide

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度The reaction was warmed to 0° C. for 4 h
2. 2
   温度cooled to -78° C
3. 3
   その他The reaction was quenched by the addition of 5 ml methanol
4. 4
   その他the solvent was evaporated
5. 5
   その他The resulting solid was recrystallized from ethanol and ether

実験手順

The product from Example 9 (0.490 g) was dissolved in 25 ml methylene chloride and cooled to -78° C. To the reaction was added 0.69 ml BBr3. The reaction was warmed to 0° C. for 4 h and then cooled to -78° C. The reaction was quenched by the addition of 5 ml methanol and the solvent was evaporated. The resulting solid was recrystallized from ethanol and ether to yield 0.470 g white solid, mp: 187°-9° C. NMR (d6DMSO) δ0.88 (t, 3H), 1.65 (m, 2H), 2.60-4.10 (m, 10H), 6.65 (d, 1H), 6.70 (d, 1H), 7.05 (t, 1H).

出典