反応 #54380

反応方程式

ozone

dimethyl sulphide

2-[4-(benzthiazol-2-yldithio)-3-phenoxyacetamido-2-oxoazetidin-1 -yl]-3-hydroxy-crotonic acid 2,2,2-trichloroethyl ester

→

2-[4-(benzthiazol-2-yldithio)-3-phenoxyacetamido-2-oxoazetidin-1-yl]-3-methylene-butyric acid 2,2,2-trichloroethyl ester

反応条件

実験手順

Analogously to Example 6a), 647 mg (1 mM) of 2-[4-(benzthiazol-2-yldithio)-3-phenoxyacetamido-2-oxoazetidin-1-yl]-3-methylene-butyric acid 2,2,2-trichloroethyl ester and 1.2 equivalents of ozone, with subsequent splitting of the ozonide with dimethyl sulphide, give 2-[4-(benzthiazol-2-yldithio)-3-phenoxyacetamido-2-oxoazetidin-1 -yl]-3-hydroxy-crotonic acid 2,2,2-trichloroethyl ester; melting point 129-130° C. (ether/petroleum ether).

出典