反応 #543553

反応方程式

Phenylalanine methyl ester

Cyclohexanoyl chloride

→

N-cyclohexanoylphenylalanine methyl ester

溶媒

pyridine

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mixture is poured onto hydrochloric acid (1N)
2. 2
   その他crushed ice
3. 3
   抽出The aqueous mixture is extracted twice with toluene
4. 4
   濃縮The combined toluene extracts are concentrated in vacuo

実験手順

Phenylalanine methyl ester (1 g., 0.0046 moles) is dissolved in pyridine 5 mL. Cyclohexanoyl chloride (0.62 mL) is added and the mixture is stirred for 2 hours. The reaction mixture is poured onto hydrochloric acid (1N) and crushed ice. The aqueous mixture is extracted twice with toluene. The combined toluene extracts are concentrated in vacuo to give 1.1 g of crude N-cyclohexanoylphenylalanine methyl ester.

出典