反応 #54348

反応方程式

hydrogen

1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-phenylpropyl)-4-piperidinol

→

title compound

3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-4-(3-phenylpropyl)-4-piperidinol

溶媒

ethanol

反応条件

後処理

1. 1
   workup.ADDITIONA mixture of 6.17 g
2. 2
   ろ過The reaction mixture is filtered through diatomaceous earth with ethyl acetate
3. 3
   その他the filtrate evaporated
4. 4
   その他The residue is purified via crystallization from ether-pentane

実験手順

A mixture of 6.17 g. (10.0 mmols.) of 1-benzyl-3-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-4-(3-phenylpropyl)-4-piperidinol, 2.0 g. of 10% palladium-on-carbon and 50 ml. of ethanol is stirred under one atmosphere of hydrogen for 2 hours. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and the filtrate evaporated. The residue is purified via crystallization from ether-pentane to yield the title compound.

出典