反応 #5432

反応方程式

N-tert-butyloxycarbonyl-L-norleucyl-proline amide

HCl dioxane

→

title compound

L-norleucyl-L-proline amide hydrochloride

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他Evaporation of solvent in vacuo
3. 3
   その他crystallization of an oily residue from methanol/ethyl ether

実験手順

The N-tert-butyloxycarbonyl-L-norleucyl-proline amide (1 g, 3.05 mmol) was placed in a round bottom flask to which freshly prepared 4N HCl/dioxane (25 ml) was added. The solution was stirred for 1 hour. Evaporation of solvent in vacuo and then crystallization of an oily residue from methanol/ethyl ether gave the title compound as a crystal-line product (0.76 g, 95%); oil, [α]D -17.7° (C=1; DMF); Rf 0.31 (1-butanol/acetic acid/water 4:1:1), Rf 0.42 (1 butanol/acetic acid/water, 4:1:5, upper phase).

出典