反応 #54266

反応方程式

isobutyraldehyde

sodium

benzhydrylammonium hypophosphite

sodium

→

1-benzhydrylamino-2-methylpropanephosphonous acid

反応条件

後処理

1. 1
   温度under reflux
2. 2
   その他80 Parts of dioxan was removed
3. 3
   workup.ADDITION150 parts of alcohol added
4. 4
   温度After cooling the mixture
5. 5
   ろ過was filtered

実験手順

7.2 parts of isobutyraldehyde in 15 parts of sodium-dried dioxan was added to a suspension of 25 parts of benzhydrylammonium hypophosphite in 150 parts of sodium-dried dioxan under reflux. 80 Parts of dioxan was removed and 150 parts of alcohol added. After cooling the mixture was filtered to give DL-1-benzhydrylamino-2-methylpropanephosphonous acid, melting point 189°-192° identical to that obtained in Example 2A.

出典