反応 #54248

反応方程式

N-phenylethylenediamine

1-benzyl-4-piperidone

sodium cyanoborohydride

→

1-benzyl-4-(2-phenylaminoethylamino)-piperidine

溶媒

methanol

methanol

hydrogen chloride

反応条件

後処理

1. 1
   ろ過After 72 hours the mixture is filtered
2. 2
   workup.DISSOLUTIONthe residue dissolved in water
3. 3
   抽出It is extracted with methylene chloride
4. 4
   その他dried
5. 5
   その他evaporated

実験手順

To the solution of 12.6 g of N-phenylethylenediamine in 200 ml of methanol, 50 ml of 4.1 N ethanolic hydrogen chloride are added dropwise followed by 18.9 g of 1-benzyl-4-piperidone in 100 ml of methanol. Then, 9.45 g sodium cyanoborohydride are added in portions while stirring at room temperature. After 72 hours the mixture is filtered, the residue dissolved in water and the solution made basic with 12.5% aqueous sodium hydroxide. It is extracted with methylene chloride, dried and evaporated to yield the 1-benzyl-4-(2-phenylaminoethylamino)-piperidine.

出典