反応 #54244

反応方程式

1-benzyl-4-piperidone

methoxyammonium chloride

→

1-benzyl-4-methoxyiminopiperidine

溶媒

反応条件

後処理

1. 1
   その他The starting material is prepared
2. 2
   その他evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in water
4. 4
   抽出extracted with diethyl ether
5. 5
   洗浄The extract is washed with water and saturated aqueous sodium hydroxide
6. 6
   その他dried
7. 7
   その他evaporated

実験手順

The starting material is prepared as follows: The solution of 94.5 g of 1-benzyl-4-piperidone and 46 g of methoxyammonium chloride in 600 ml of ethanol-pyridine (1:1) is refluxed overnight and evaporated. The residue is dissolved in water, the solution made basic with 12.5% aqueous sodium hydroxide and extracted with diethyl ether. The extract is washed with water and saturated aqueous sodium hydroxide, dried and evaporated, to yield the 1-benzyl-4-methoxyiminopiperidine.

出典