反応 #54183

反応方程式

tetrahydrofuran

bromine

1(2-furyl)-1-ethanol

→

Maltol

収率 53.0%

溶媒

water

反応条件

後処理

1. 1
   その他To a 4-neck round bottom flask equipped with a thermometer
2. 2
   workup.ADDITIONa condensor and two addition funnels
3. 3
   温度The temperature of the reaction was maintained at 15° C. throughout the double addition
4. 4
   温度The reaction mixture was then heated to 75° C. for 10 hours

実験手順

To a 4-neck round bottom flask equipped with a thermometer, a condensor and two addition funnels was charged 50 ml of tetrahydrofuran and 50 ml of water and the solution was cooled to 10° C. To this well stirred solution was added together in the two addition funnels bromine (0.20 mole) and 1(2-furyl)-1-ethanol (0.09 mole). The temperature of the reaction was maintained at 15° C. throughout the double addition. The reaction mixture was then heated to 75° C. for 10 hours. Maltol was isolated by the procedure of Example 1 (53% yield).

出典