反応 #54151

反応方程式

2-hydroxy-4-methoxybenzaldehyde

ethyl acetoacetate

→

3-acetyl-7-methoxycoumarin

反応条件

後処理

1. 1
   温度was warmed on a hot plate until solution
2. 2
   温度to be heated gently
3. 3
   workup.WAITAfter several minutes the reaction mixture solidified
4. 4
   温度After cooling
5. 5
   その他the product was recrystallized from a mixture of alcohol and acetonitrile

実験手順

A mixture of 15.2 g 2-hydroxy-4-methoxybenzaldehyde and 13.5 g ethyl acetoacetate was warmed on a hot plate until solution was attained. Thirty drops of piperidine were added and the reaction mixture continued to be heated gently. After several minutes the reaction mixture solidified. After cooling, the product was recrystallized from a mixture of alcohol and acetonitrile. Yield 20 g.

出典