反応 #54140
ord-cb847d7ade3d49c2ad756e823e9807e5
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1抽出The solution was extracted with 1N HCl solution
- 2抽出extracted with CH2Cl2
- 3乾燥dried (MgSO4)
- 4ろ過filtered
- 5濃縮concentrated in vacuo
- 6その他to give a white solid
実験手順
Nicotinoyl chloride hydrochloride (0.3 g, 1.685 mmol), DIEA (0.65 g, 5.06 mmol, 3.0 eqv), and ortho- or meta-anisidine (0.21 g, 1.68 mmol, 1 eqv) were dissolved in CH2Cl2 and stirred at rt for 48 h. The solution was extracted with 1N HCl solution. The aqueous layer was neutralized with a NaHCO3 solution and extracted with CH2Cl2. The organic extracts were combined, dried (MgSO4), filtered, and concentrated in vacuo to give a white solid.