反応 #54084

ord-7c56a04383ed4063bf8cdbd4df45e8e4

反応方程式

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1cccc(B(O)O)c1
3-methoxyphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol
→
COc1cccc(-c2ccc3c(c2)C(CSCCc2ccccc2)=CC(C)(C)N3)c1
title compound
COc1cccc(-c2ccc3c(c2)C(CSCCc2ccccc2)=CC(C)(C)N3)c1
6-(3-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

反応物

CC1=CC(C)(C)Nc2ccc(OS(=O)(=O)C(F)(F)F)cc21
Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester
COc1cccc(B(O)O)c1
3-methoxyphenylboronic acid
SCCc1ccccc1
2-phenylethanethiol

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 3-methoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 21 mg of the title compound.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06858627B2uspto-grants-2005_02