反応 #540285

反応方程式

4-benzyloxybenzonitrile

KOH

→

product

収率 101.3%

4-Benzyloxybenzamide

収率 101.3%

溶媒

brine

tert-butanol

反応条件

後処理

1. 1
   その他the resulting reaction mixture
2. 2
   その他After the completion of the reaction (TLC monitoring)
3. 3
   抽出extracted with ethyl acetate (3×50 ml)
4. 4
   乾燥The combined organic layer was dried over Na2SO4
5. 5
   ろ過filtered
6. 6
   濃縮concentrated under vacuum

実験手順

To a solution of 4-benzyloxybenzonitrile (0.61 g, 2.91 mmol) in 15 ml of tert-butanol was added fine powder of KOH (1.22 g, 21.78 mmol) and the resulting reaction mixture was refluxed for 4 h at 78° C. After the completion of the reaction (TLC monitoring), added brine solution and extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum, to get the product (0.67 g) that was used as such for the next step.

出典