反応 #53935

反応方程式

trans-[4-(5-Bromo-pentyl)-cyclohexyl]-methyl-carbamic acid benzyl ester

→

trans-[4-(5-Bromo-pentyl)-cyclohexyl]-methyl-amine hydrobromide

収率 179.2%

溶媒

HBr

反応条件

後処理

1. 1
   その他the reaction was evaporated
2. 2
   その他evaporated again
3. 3
   ろ過filtered

実験手順

22.55 g (56.89 mmol) of trans-[4-(5-Bromo-pentyl)-cyclohexyl]-methyl-carbamic acid benzyl ester were dissolved at RT in 100 ml HBr (33% in acetic acid). After 20 min, the reaction was evaporated, suspended in toluene (2×) and evaporated again. The suspension was taken up in hexane and filtered to give 17.49 g (90%) of trans-[4-(5-Bromo-pentyl)-cyclohexyl]-methyl-amine hydrobromide, MS: 262 (MH+, 1Br).

出典