反応 #53909

反応方程式

2-(2-Hydroxy-ethylamino)-ethanol

trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester

trifluoro-acetic acid

4-trifluoromethyl-phenyl-sulfonylchloride

→

trans N-(4-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide

反応条件

実験手順

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with 2-(2-Hydroxy-ethylamino)-ethanol to give trans N-(4-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 481 (MH+).

出典